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Science 24 October 1997:
Vol. 278. no. 5338, pp. 680 - 686
DOI: 10.1126/science.278.5338.680
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Reports

Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale

Joseph L. DeRisi, Vishwanath R. Iyer, Patrick O. Brown *

DNA microarrays containing virtually every gene of Saccharomyces cerevisiae were used to carry out a comprehensive investigation of the temporal program of gene expression accompanying the metabolic shift from fermentation to respiration. The expression profiles observed for genes with known metabolic functions pointed to features of the metabolic reprogramming that occur during the diauxic shift, and the expression patterns of many previously uncharacterized genes provided clues to their possible functions. The same DNA microarrays were also used to identify genes whose expression was affected by deletion of the transcriptional co-repressor TUP1 or overexpression of the transcriptional activator YAP1. These results demonstrate the feasibility and utility of this approach to genomewide exploration of gene expression patterns.

Department of Biochemistry, Stanford University School of Medicine, Howard Hughes Medical Institute, Stanford, CA 94305-5428, USA.
*   To whom correspondence should be addressed. E-mail: pbrown{at}cmgm.stanford.edu

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L. A. Marcelino, V. Backman, A. Donaldson, C. Steadman, J. R. Thompson, S. P. Preheim, C. Lien, E. Lim, D. Veneziano, and M. F. Polz (2006)
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   Abstract »    Full Text »    PDF »
Transcriptional Organization and Regulation of Magnetosome Operons in Magnetospirillum gryphiswaldense.
S. Schubbe, C. Wurdemann, J. Peplies, U. Heyen, C. Wawer, F. O. Glockner, and D. Schuler (2006)
Appl. Envir. Microbiol. 72, 5757-5765
   Abstract »    Full Text »    PDF »
Metabolic-State-Dependent Remodeling of the Transcriptome in Response to Anoxia and Subsequent Reoxygenation in Saccharomyces cerevisiae..
L.-C. Lai, A. L. Kosorukoff, P. V. Burke, and K. E. Kwast (2006)
Eukaryot. Cell 5, 1468-1489
   Abstract »    Full Text »    PDF »
Promotion of oogenesis and embryogenesis in the C. elegans gonad by EFL-1/DPL-1 (E2F) does not require LIN-35 (pRB).
W. Chi and V. Reinke (2006)
Development 133, 3147-3157
   Abstract »    Full Text »    PDF »
Identifying transcription factor functions and targets by phenotypic activation.
G. Chua, Q. D. Morris, R. Sopko, M. D. Robinson, O. Ryan, E. T. Chan, B. J. Frey, B. J. Andrews, C. Boone, and T. R. Hughes (2006)
PNAS 103, 12045-12050
   Abstract »    Full Text »    PDF »


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